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Effect of MTX with or without diosmin on proinflammatory cytokines IL-1β, IL-6, and TNF-α. DM: diosmin; IL: interleukin; MTX: methotrexate; TNF: tumor necrosis factor. ∗Significant change at p < 0.01 with respect to the negative control group. #Significant change at p < 0.01 with respect to the MTX group as the positive control group.
