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. 2017 Jul 27;2017:4386947. doi: 10.1155/2017/4386947

Figure 4.

Figure 4

Effect of DUSP6 siRNA silencing on ERK signaling in normoxia and hypoxia in wild-type ES cells (a). Densitometry analysis of western blot expressed as fold change in ERK phosphorylation (b). Data are presented as mean + SEM from at least three independent experiments. Statistical significance was determined by one-way analysis of variance ANOVA and post hoc Bonferroni's multiple comparison test (∗P < 0.05). Effect of 3 h, 6 h, 12 h, and 24 h 1% O2 cultivation on DUSP6 protein expression and ERK phosphorylation in wild-type ES cells (c). Total level of β-actin was used as a loading control.