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. 2017 Jun 2;158(8):2486–2502. doi: 10.1210/en.2017-00111

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This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 5. — Histological analysis of Nuf mice pancreatic islets. (a) Representative H&E-stained pancreatic sections from Casr^+/+, Casr^Nuf/+, and Casr^Nuf/Nuf mice. Bars indicate 200 μm. (b) Islet area and (c) number are significantly reduced in Casr^Nuf/+ and Casr^Nuf/Nuf mice compared with Casr^+/+ mice. (d) Islet size is significantly reduced in Casr^Nuf/Nuf mice compared with Casr^+/+ mice. (e) Representative pancreatic islets from Casr^+/+, Casr^Nuf/+, and Casr^Nuf/Nuf mice immunostained for glucagon (red), insulin (white), and DAPI (blue). Bars indicate 50 μm. (f) Casr^Nuf/Nuf mice have significantly reduced β-cell numbers and (g) significantly increased α-cell numbers compared with Casr^+/+ mice. (h) β-cell proliferation in representative islets from Casr^+/+, Casr^Nuf/+, and Casr^Nuf/Nuf mice immunostained for insulin (white), DAPI (blue), and KI-67 (red). KI-67–positive cells are also indicated by yellow arrows. Bars indicate 50 μm. (i) Casr^Nuf/Nuf mice have significantly reduced proliferation of β-cells and (j) significantly increased proliferation of α-cells compared with respective Casr^+/+ mice. Results are expressed as mean ± standard error of the mean. *P < 0.05, **P < 0.01 compared with Casr^+/+ mice.