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. 2017 Jun 2;158(8):2486–2502. doi: 10.1210/en.2017-00111

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Figure 7. — Effect of glucose stimulation on the electrical activity of Nuf mice β-cells. (a) Representative membrane potential recording of β-cells from intact Casr^+/+ and Casr^Nuf/Nuf islets, which had been incubated in 1.5 mM [Ca²⁺]_o and following stimulation with 1 mM (1G), 12 mM (12G), and 20 mM (20G) glucose concentrations or with tolbutamide (Tolb). (b) Representative membrane potential recording of β-cells from intact Casr^+/+ and Casr^Nuf/Nuf islets in the presence of 0.75 mM Ca²⁺_o concentrations and following stimulation with 1, 12, or 20 mM glucose concentrations or with tolbutamide. (c) Basal membrane potential, (d) action potential peak, (e) antipeak potential, and (f) frequency of action potential firing from β-cells was assessed in intact Casr^+/+ (white bars) and Casr^Nuf/Nuf islets (black bars) in the presence of 1.5 or 0.75 mM Ca²⁺_o concentrations and following stimulation with glucose or tolbutamide. The sample size (N) represents individual β-cell recordings obtained from intact islets of six Casr^+/+ mice and four Casr^Nuf/Nuf mice. Results are expressed as mean ± standard error of the mean. *P < 0.05, **P < 0.01 compared with Casr^+/+ mice at respective glucose and Ca²⁺_o concentrations.