Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 2;158(8):2486–2502. doi: 10.1210/en.2017-00111

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

PMC Copyright notice

Figure 8. — K_ATP channel conductance of Nuf mice β-cells. (a) Representative recording of β-cell K_ATP channel conductance from intact Casr^+/+ and Casr^Nuf/Nuf islets after islets had been incubated in 1.5 mM [Ca²⁺]_o and following stimulation with 1 mM (1G), 12 mM (12G), and 20 mM (20G) glucose concentrations or with tolbutamide (Tolb). (b) Analysis of K_ATP channel conductance from β-cells within intact Casr^+/+ (white bars) and Casr^Nuf/Nuf islets (black bars) following stimulation with glucose or tolbutamide. (c) Representative traces of β-cell background current measurement following glucose stimulation or treatment with tolbutamide. (d) Analysis of holding current from β-cells within intact Casr^+/+ (white bars) and Casr^Nuf/Nuf islets (black bars) following stimulation with glucose or tolbutamide. The sample size (N) represents individual β-cell recordings obtained from intact islets of five Casr^+/+ mice and five Casr^Nuf/Nuf mice. Results are expressed as mean ± standard error of the mean. *P < 0.05, **P < 0.01 compared with Casr^+/+ mice at respective glucose and tolbutamide concentrations.