Figure 1.
Network of proteins capable of physically interacting with C3. The network in its entirety is significantly enriched (P < 10−6) for signals in gene expression (case vs control) of 10 independent human islet preparations left untreated or treated with IL-1β plus IFN-γ (50 and 1000 U/mL, respectively) for 48 hours. Protein–protein interactions are based on a high-confidence subset of InWeb_IM (confidence score > 0.1). Green symbols indicate extracellular; triangle symbols indicate receptor.