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. Author manuscript; available in PMC: 2018 Aug 2.
Published in final edited form as: Nat Prod Rep. 2017 Aug 2;34(8):981–1009. doi: 10.1039/c7np00029d

Fig. 7.

Fig. 7

Acinetobactin biosynthesis. N-hydroxyhistamine is produced through the activites of BasG and BasC. The intermolecular loading of DHB on the carrier domain of BasF has been demonstrated biochemically while the subsequent reactions are assumed based on the homologous reactions of pseudomonine biosynthesis. The tandem cyclization domains of BasD perform the peptide bond formation and cyclization to form the oxazoline ring. The condensation domain of BasB then transfers the DHB-oxazoline to 13 to result in the formation of pre-acinetobactin 14.