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The ability of double-stranded DNAs containing dG (DNA15G), acyclovir (DNA16ACV), gancicyclovir (DNA16GCV), and dideoxyG (DNA16dd) to inhibit exonuclease activity on 1 μM 5′-[32P]-labeled single-stranded DNA (DNA35ss) or 1 μM 5′-[32P]-labeled double-stranded DNA (DNA35C).
| Inhibitor DNA | Substrate DNA | IC50 (μM) |
|---|---|---|
| DNA16GCV | DNA35C | 1.0 |
| DNA16ACV | DNA35C | 1.7 |
| DNA16dd | DNA35C | 2.5 |
| DNA15G | DNA35C | 1.3 |
| DNA16GCV | DNA35ss | 0.6 |
| DNA16ACV | DNA35ss | 1.0 |
| DNA16dd | DNA35ss | 0.3 |
| DNA15G | DNA35ss | 0.3 |
