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. 2017 Aug 7;216(8):2339–2354. doi: 10.1083/jcb.201512055

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© 2017 Cullati et al.

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Figure 9. — Model for Nek kinase-dependent signaling modules that specify anaphase behavior of Mklp2 and Kif14. For Mklp2, preanaphase cells contain high Cdk1 and Nek activity, rendering Mklp2 cytosolic and inactive. Dephosphorylation at anaphase onset by loss of Cdk1 activity and/or gain of phosphatase activity while maintaining Nek-dependent phosphorylation status licenses Mklp2 for deposition to the anaphase central spindle. Residence at the anaphase central spindle then registers it via an unknown mechanism for functions in telophase and beyond; analogous mechanisms are proposed to exist for Kif14. Pptase, phosphatase.