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. 2017 Aug 7;216(8):2355–2371. doi: 10.1083/jcb.201610071

Figure 8.

Figure 8.

Siz1 promotes de novo telomere addition in rad52Δ cells. (A) Quantification of de novo telomere addition events. Values are reported as fold over wild-type (WT). n = 9–34 cultures. Error bars represent ± 95% confidence interval. *, P < 0.05; ***, P < 0.005 (Mann–Whitney t test). (B) The pif1-m2 mutant reduces the nucleolar accumulation of TLC1 RNA in rad52Δ siz1Δ cells. Nuclear distribution of TLC1 RNA in rad52Δ, siz1Δ rad52Δ, and pif1-m2 siz1Δ rad52Δ cells, with (+) or without (−) exposure to bleomycin (blm). Error bars represent ±SD; n = 200–300 cells. ****, P < 0.0001 (two-tailed t test).