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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: DNA Repair (Amst). 2017 Jun 9;56:7–15. doi: 10.1016/j.dnarep.2017.06.002

Figure 3. Duplex Sequencing eliminates artifacts.

Figure 3

(A) The active site exons of the ABL1 gene were isolated by double-capture and sequenced by conventional NGS on an Illumina Hiseq 2500 (minimum Phred score=50). (B) The same DNA sample was subject to Duplex Sequencing, revealing only a single point mutation in ABL1 that confers resistance to Imatinib. Adapted from [24].