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. 2017 Aug 4;8:4–7. doi: 10.1016/j.jbo.2017.07.001

Table 1.

Risk factors for osteosarcoma [3], [6], [12], [13], [14], [15], [16].

Other diseases as risk factors Other risk factors
Previous osteomyelitis Hispanic and African heritage
Paget’s bone disease (elderly populations) Tall stature/large growth spurts
Hereditary Multiple Osteochondromas Previous localised radiation treatment
Familial gene mutations, including:
  • –

    RB1 (Retinoblastoma)

  • –

    REQL4 (Rothmund-Thomson)

  • –

    BLM (Bloom)

  • –

    WRN (Werner)

  • –

    p53 (Li-Fraumeni Syndrome)

  • –

    Diamond-Blackfan Anaemia

 Being aged between 10 and 19, or older than 65.
Being female (in elderly populations)
Being male (in young populations)