Table 2.

Factors affecting osteosarcoma prognosis [1], [3], [4], [12], [17], [18], [19], [20], [21], [22], [23].

Factors supporting a positive outcome for the patient	Factors supporting a negative outcome for the patient
> 90% necrosis in response to neoadjuvant (induction) chemotherapy	< 90% necrosis in response to neoadjuvant chemotherapy
Wide surgical margin upon resection	Age > 40 years
Early diagnosis	Tumour located in the axial skeleton
Diagnosis before 12 years of age	Metastases at diagnosis
	Osteoblastic subtype
	Unresectable tumour
	Pathological fractures
	High serum concentration of vascular endothelial growth factor (VEGF)