Table 3.
Cumulative tar and pack-years and risk of overall, small cell and squamous cell lung cancer
| Variable | Controls N (%) |
Lung N (%) |
Adjusted OR (95% CL’s)1 |
Small cell N (%) |
Adjusted OR (95% CL’s)1 |
Squamous N (%) |
Adjusted OR (95% CL’s)1 |
|---|---|---|---|---|---|---|---|
| Cumulative tar | |||||||
| Per IQR Increase | 1.61 (1.50, 1.73) | 1.63 (1.44, 1.84) | 1.71 (1.51, 1.92) | ||||
| Never Smokers | 491 (47.2) | 110 (18) | 1 (Reference) | 4 (5.3) | 1 (Reference) | 8 (8.4) | 1 (Reference) |
| Tertile 1 | 169 (16.3) | 34 (5.6) | 0.95 (0.60, 1.49) | 2 (2.7) | 1.70 (0.29, 9.80) | 3 (3.2) | 0.93 (0.24, 3.65) |
| Tertile 2 | 169 (16.3) | 130 (21.3) | 3.48 (2.47, 4.90) | 18 (24) | 17.63 (5.22, 59.61) | 18 (18.9) | 5.09 (2.08, 12.41) |
| Tertile 3 | 168 (16.2) | 324 (53) | 10.43 (7.34, 14.81) | 49 (65.3) | 45.97 (13.68, 154.48) | 63 (66.3) | 19.00 (8.02, 45.03) |
| p-trend<0.0001 | p-trend<0.0001 | p-trend<0.0001 | |||||
| Cigarette pack-years | |||||||
| Per IQR Increase | 2.16 (1.96, 2.39) | 2.26 (1.89, 2.70) | 2.41 (2.03, 2.88) | ||||
| Never Smokers | 491 (47.2) | 110 (18) | 1 (Reference) | 4 (5.3) | 1 (Reference) | 8 (8.4) | 1 (Reference) |
| Tertile 1 | 183 (17.6) | 27 (4.4) | 0.75 (0.47, 1.21) | 1 (1.3) | 0.86 (0.09, 8.06) | 3 (3.2) | 1.06 (0.27, 4.15) |
| Tertile 2 | 183 (17.6) | 86 (14.1) | 2.14 (1.49, 3.07) | 12 (16) | 10.58 (3.14, 35.58) | 10 (10.5) | 2.49 (0.93, 6.65) |
| Tertile 3 | 182 (17.5) | 388 (63.5) | 11.82 (8.42, 16.61) | 58 (77.3) | 54.30 (16.76, 175.96) | 74 (77.9) | 22.68 (9.79, 52.57) |
| p-trend<0.0001 | p-trend<0.0001 | p-trend<0.0001 |
1
Models adjusted for age, race/ethnicity, sex, years of education and drink-years.