Table 4.
Cumulative tar and pack-years and risk of lung adenocarcinoma and large cell lung cancer
| Variable | Controls N (%) |
Adenocarcinoma N (%) |
Adjusted OR (95% CL’s)1 |
Large cell N (%) |
Adjusted OR (95% CL’s)1 |
|---|---|---|---|---|---|
| Cumulative tar | |||||
| Per IQR Increase | 1.42 (1.30, 1.54) | 1.62 (1.45, 1.81) | |||
| Never smokers | 491 (47.2) | 77 (26.6) | 1 (Reference) | 14 (12.2) | 1 (Reference) |
| Tertile 1 | 169 (16.3) | 17 (5.9) | 0.69 (0.38, 1.23) | 5 (1.7) | 1.12 (0.38, 3.27) |
| Tertile 2 | 169 (16.3) | 70 (24.1) | 2.64 (1.76, 3.96) | 19 (6.6) | 4.02 (1.88, 8.60) |
| Tertile 3 | 168 (16.2) | 121 (41.7) | 5.71 (3.75, 8.70) | 75 (25.9) | 17.25 (8.48, 35.10) |
| p-trend<0.0001 | p-trend<0.0001 | ||||
| Cigarette pack-years | |||||
| Per IQR Increase | 1.77 (1.58, 1.98) | 2.18 (1.86, 2.55) | |||
| Never smokers | 491 (47.2) | 77 (26.6) | 1 (Reference) | 14 (12.2) | 1 (Reference) |
| Tertile 1 | 183 (17.6) | 15 (5.2) | 0.59 (0.32, 1.08) | 3 (2.6) | 0.68 (0.19, 2.43) |
| Tertile 2 | 183 (17.6) | 46 (15.9) | 1.66 (1.07, 2.58) | 13 (11.3) | 2.47 (1.09, 5.56) |
| Tertile 3 | 182 (17.5) | 152 (52.4) | 6.56 (4.39, 9.81) | 85 (73.9) | 18.16 (9.11, 36.22) |
| p-trend<0.0001 | p-trend<0.0001 |
1
Models adjusted for age, race/ethnicity, sex, years of education and drink-years.