Table 5.
Cumulative tar and pack-years and risk of overall UADT cancer, UADT squamous cell carcinoma and esophageal adenocarcinoma
| Variable | Controls N (%) |
UADT N (%) |
Adjusted OR (95% CL’s)1 |
Squamous N (%) |
Adjusted OR (95% CL’s)1 |
Esophageal adenocarcinoma N (%) |
Adjusted OR (95% CL’s)1 |
|---|---|---|---|---|---|---|---|
| Cumulative tar | |||||||
| Per IQR Increase | 1.21 (1.13, 1.29) | 1.18 (1.10, 1.27) | 1.27 (1.13, 1.43) | ||||
| Never smokers | 491 (47.2) | 182 (30.3) | 1 (Reference) | 149 (30) | 1 (Reference) | 18 (24.3) | 1 (Reference) |
| Tertile 1 | 169 (16.3) | 50 (8.3) | 0.70 (0.48, 1.03) | 41 (8.2) | 0.69 (0.46, 1.05) | 6 (8.1) | 0.82 (0.31, 2.19) |
| Tertile 2 | 169 (16.3) | 122 (20.3) | 1.53 (1.11, 2.10) | 98 (19.7) | 1.43 (1.02, 2.01) | 17 (23.0) | 2.52 (1.21, 5.25) |
| Tertile 3 | 168 (16.2) | 221 (36.8) | 1.97 (1.42, 2.74) | 185 (37.2) | 1.79 (1.26, 2.54) | 31 (41.9) | 3.54 (1.69, 7.43) |
| p-trend<0.0001 | p-trend=0.0005 | p-trend=0.0003 | |||||
| Cigarette pack-years | |||||||
| Per IQR Increase | 1.36 (1.25, 1.49) | 1.33 (1.21, 1.46) | 1.46 (1.24, 1.73) | ||||
| Never smokers | 491 (47.2) | 182 (30.3) | 1 (Reference) | 149 (30) | 1 (Reference) | 18 (24.3) | 1 (Reference) |
| Tertile 1 | 183 (17.6) | 50 (8.3) | 0.69 (0.48, 1.01) | 41 (8.2) | 0.69 (0.46, 1.04) | 7 (9.5) | 0.86 (0.34, 2.19) |
| Tertile 2 | 183 (17.6) | 106 (17.6) | 1.24 (0.90, 1.70) | 85 (17.1) | 1.18 (0.84, 1.67) | 14 (18.9) | 1.83 (0.85, 3.91) |
| Tertile 3 | 182 (17.5) | 263 (43.8) | 2.39 (1.75, 3.26) | 222 (44.7) | 2.22 (1.59, 3.09) | 35 (47.3) | 3.69 (1.82, 7.52) |
| p-trend<0.0001 | p-trend<0.0001 | p-trend=0.0002 |
1
Models adjusted for age, race/ethnicity, sex, years of education and drink-years.