Table 6.
Cumulative tar exposure and risk of lung and UADT cancer and subtypes, adjusted for pack-years in maximum-likelihood and semi-Bayes models
| Cancer type | Maximum-likelihood adjusted OR (95% CL’s)1 |
Semi-Bayes adjusted OR (95% posterior limits)1 |
|---|---|---|
| Overall lung cancer | ||
| Per IQR Increase | 0.99 (0.86, 1.13) | 0.96 (0.84, 1.10) |
| Never smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.73 (0.46, 1.17) | 0.73 (0.47, 1.12) |
| Tertile 2 | 1.47 (0.98, 2.21) | 1.55 (1.07, 2.24) |
| Tertile 3 | 1.56 (0.88, 2.76) | 1.47 (0.88, 2.45) |
| p-trend = 0.09 | p-trend=0.05 | |
| Small cell lung cancer | ||
| Per IQR Increase | 0.93 (0.73, 1.18) | 0.93 (0.74, 1.18) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 1.48 (0.25, 8.61) | 0.82 (0.30, 2.22) |
| Tertile 2 | 8.79 (2.47, 31.37) | 2.73 (1.33, 5.61) |
| Tertile 3 | 7.61 (1.81, 32.08) | 2.06 (0.88, 4.82) |
| p-trend= 0.002 | p-trend=0.004 | |
| Squamous cell lung cancer | ||
| Per IQR Increase | 1.12 (0.92, 1.36) | 1.07 (0.89, 1.29) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.52 (0.11, 2.44) | 0.67 (0.26, 1.73) |
| Tertile 2 | 1.66 (0.62, 4.44) | 1.59 (0.78, 3.21) |
| Tertile 3 | 1.53 (0.47, 5.03) | 1.30 (0.57, 2.97) |
| p-trend= 0.35 | p-trend=0.26 | |
| Lung adenocarcinoma | ||
| Per IQR Increase | 0.93 (0.78, 1.10) | 0.91 (0.77, 1.07) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.59 (0.33, 1.07) | 0.62 (0.37, 1.05) |
| Tertile 2 | 1.50 (0.94, 2.42) | 1.56 (1.02, 2.37) |
| Tertile 3 | 1.56 (0.79, 3.08) | 1.41 (0.78, 2.54) |
| p-trend=0.15 | p-trend=0.10 | |
| Large cell lung cancer | ||
| Per IQR Increase | 1.07 (0.88, 1.29) | 1.06 (0.88, 1.27) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.92 (0.31, 2.74) | 0.80 (0.36, 1.79) |
| Tertile 2 | 2.07 (0.91, 4.74) | 1.57 (0.83, 2.98) |
| Tertile 3 | 3.77 (1.43, 9.91) | 2.51 (1.20, 5.25) |
| p-trend=0.007 | p-trend=0.003 | |
| Overall UADT cancer | ||
| Per IQR Increase | 0.96 (0.84, 1.10) | 0.98 (0.86, 1.12) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.61 (0.41, 0.90) | 0.64 (0.44, 0.93) |
| Tertile 2 | 0.91 (0.63, 1.34) | 0.95 (0.67, 1.35) |
| Tertile 3 | 0.59 (0.33, 1.05) | 0.66 (0.40, 1.10) |
| p-trend= 0.13 | p-trend=0.14 | |
| UADT squamous cell carcinoma | ||
| Per IQR Increase | 0.94 (0.82, 1.09) | 0.96 (0.83, 1.10) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.60 (0.39, 0.92) | 0.64 (0.43, 0.94) |
| Tertile 2 | 0.86 (0.57, 1.30) | 0.92 (0.64, 1.33) |
| Tertile 3 | 0.56 (0.30, 1.03) | 0.64 (0.37, 1.10) |
| p-trend=0.09 | p-trend=0.10 | |
| Esophageal adenocarcinoma | ||
| Per IQR Increase | 1.02 (0.80, 1.30) | 1.07 (0.85, 1.34) |
| Never Smokers | 1 (Reference) | 1 (Reference) |
| Tertile 1 | 0.75 (0.28, 2.01) | 0.83 (0.38, 1.78) |
| Tertile 2 | 1.69 (0.76, 3.78) | 1.44 (0.76, 2.72) |
| Tertile 3 | 1.22 (0.39, 3.82) | 1.12 (0.49, 2.56) |
| p-trend=0.45 | p-trend=0.43 |
1
Models adjusted for age, race/ethnicity, sex, years of education, drink-years and pack-years.