Figure 6.

Validation of the Cellular Specificity of the L7-6 by Intravenous Administration of AAV PHP.B Vectors That Are Highly Permeable to the Blood-Brain Barrier

(A–D) Bright-field (A and C) and native GFP fluorescent (B and D) images of the whole brain and the sagittal section. The mouse received intravenous injection of 100 μL of AAV PHP.B (3.0 × 10¹³ viral genomes/mL) and was sacrificed 3 weeks post-injection. (E) Magnification of the GFP fluorescent image at the cerebellar cortex. Scale bars, 2 mm (AD) and 50 μm (E).