Skip to main content
. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Dev Dyn. 2017 Jul 19;246(9):670–681. doi: 10.1002/dvdy.24537

Figure 3.

Figure 3

Rescue embryos have oral adhesions and cleft palate at birth. Head coronal sections of perinatal pups stained with H&E. A–C) anterior, D–F) middle and G–I) posterior oral cavities of wildtype (A, D, G), rescue (B, E, H) and knockout (C, F, I) pups. The oral cavity of rescue pups is less severely affected overall but oral adhesions persist bilaterally in the anterior oral cavity (B) and in the middle oral cavity between the maxilla and mandible at the tooth germ (E). In the posterior palate of rescue embryos (H), adhesions and a fusion (black arrow head, enlarged with inset) is observed between the palate and the tongue. (A) Scale bar = 500 μm. T, Tongue; PS, palatal shelves.