Figure 4.

Comparison of electrical mapping with optical fluorescence recording. (a) Representative electrical and optical signals captured simultaneously on a Langendorff-perfused rabbit heart at multiple cycle lengths (300, 250, and 200 ms). (b) Interpolated spatial activation maps derived from these data. Top row shows activation as measured during sinus rhythm. The bottom row corresponds to 300 ms ventricular pacing. The activation maps from left to right are optical signals from the whole heart, optical signals from the device area, and electrical signals respectively. The dashed boxes in the whole heart illustrations depict the device area. (c) Comparison of activation and repolarization measurements in a single simultaneously measured electrical and optical signals. Left figure highlights a quantitative comparison of electrical and optical signals during one depolarization/repolarization cycle. Center figure shows the comparison of activation times measured across all electronic nodes and corresponding optical field of view. Right figure shows the comparison of optical and electrical restitution curves measured at various cycle lengths (300, 250, 225, 200, 175 ms).