Table 2.

Percent Identity comparisons of the DNA binding domain (DBD) and ligand binding domain (LBD) of orthologous human and F. heteroclitus nuclear receptors with Blastp.

Nuclear Receptora	DBD	LBD	Ligandsb
SHP		51
DAX		51
THRα1-110	92	84	Thyroid hormones (114)
THRα2-10098	96	91
PPARα1	86	85	Leukotriene B4, 1-palmityl-2-oleolyl-sn-glycerol-3-phosphocholine, Fatty acids (115)
PPARα2	86	73
Rev-Erb-β1-10090	94	83	Heme (114)
Rev-Erb-β2-10062	93	77
RORα-9958	99	93
RORα-369	91	75
RORγ-9885	90	43
RORγ-10005	90	47
FXR1-10028	96	72	5β-bile acids (83)
FXR2-9861	84	35
VDR-A	93	79	1,25-OH vitamin D3, bile salts (116,117)
VDR-B	94	80
PXR	72	58	Xenobiotics, bile salts (73,80)
RXRβ1-483	94	88	9-cis retinoic acid, rexinoids (114,118)
RXRβ2-9867	90	79
RXRγ1-9885	94	95
RXRγ2-9880	94	95
PNR1-9949	93	74
PNR2-195	91	59
ESR1	96	66	17β-estradiol (119)
ESR2α – 10024	96	68
ESR2β – 10026	96	65
ERRβ-9910	100	76
ERRβ-3	100	84
ERRγ _10140	97	94
ERRγ2 _9925	91	81
GR - 0	96	74	Cortisol (120)
GR2 -10031	96	74
ARα-9941	65	59	Testosterone, 11-ketotestosterone, 17α-methyltestosterone (121)
ARβ-9884	91	70
NGF1B	99	69
Nurr77	93	66
NURR1a-9995	96	95
NURR1b-114	97	58
SF1a	72	58	Phosphatidylinositol, phosphatidylcholine (122)
FTZ-F2/SF1b-224	84	nd

^aScaffold is often provided after the receptor to aid in determining the receptor in question.

^bKnown or putative endogenous physiological ligands for fish (or human if fish unknown) are included for the receptors that show show high divergence from humans or have a duplicated receptor with potential neofunctionalization.