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. Author manuscript; available in PMC: 2017 Aug 10.
Published in final edited form as: Macromolecules. 2013 Nov 27;46(23):9169–9180. doi: 10.1021/ma401529w

Figure 9.

Figure 9

A combination index (C.I.) plot showing the enhanced synergy observed when a dual drug-loaded PCN is used against MDA-MB-231 human breast cancer cells. Combination index were plotted on a logarithmic scale against drug effect levels. (Drug effect level is the reverse of inhibitory concentration. A drug effect level of 70% is equivalent to an IC30 value, the concentration where only 30% of the cell is viable). A combination index of 1 represents just an additive effect (i.e., the drugs are neither reinforcing or working against each other) and combination index values that are lower than 1 mean enhanced synergy in drug combination.80 The dual-drug PCN is clearly more synergistic than either the analogous combinations of single-drug-loaded PCNs or the free drugs.