Table 1. Composition and properties of the LNCs.
Formulation codes | Macrogol 15 hydroxystearate/triglycerides MMR | Macrogol 15 hydroxystearate | Lecithin | Caprylic/capric acid triglycerides | PS (nm) | PDI | ZP (mV) |
---|---|---|---|---|---|---|---|
LNC30 | 2.29 | 67.75% | 2.63% | 29.62% | 26.7±0.1 | 0.036±0.004 | -7.14±0.33 |
LNC60 | 0.82 | 43.38% | 3.85% | 52.77% | 56.0±1.0*** | 0.028±0.016* | -6.33±1.32** |
LNC100 | 0.40 | 27.33% | 4.24% | 68.42% | 100.0±2.2 | 0.047±0.013 | -10.62±1.90 |
LNC81 | 0.82 | 45.12% | 0.00% | 54.88% | 81.0±3.4 | 0.086±0.015 | -1.8±0.40 |
LNC44 | 0.82 | 41.71% | 7.43% | 50.86% | 44.0±0.1*** | 0.041±0.010* | -12.3±3.0** |
LNC40 | 0.82 | 40.29% | 10.71% | 49.00% | 40.0±0.3*** | 0.033±0.010** | -23.4±2.4*** |
*p<0.05
**p<0.01
***p<0.001 versus LNCs without lecithin (LNC81).