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. 2017 Aug 10;12(8):e0182993. doi: 10.1371/journal.pone.0182993

Fig 1. Domain organization of LytS/LytTR histidine kinase/response regulator.

Fig 1

HKs of the LytS family contain a 5TM-5TMR_LYT domain (pfam07694) and a GAF domain, which together form the input domain. The cytosolic DHp [harboring a conserved histidine (His)] and CA modules in the HKs serve as the transmitter domain. The RR belongs to the LytTR-type family of transcriptional activators and comprises a CheY-like receiver domain [harboring a conserved aspartate (Asp)], and a LytTR-type effector domain made up of a 10-stranded β-fold DNA-binding domain.