Table 1. Treatment groups for toxicological and bio-distribution studies–allocation and dosing.

Group Designation	Dose	No. of animals
		males	females
C-BIO(Control)	0 (i.c./i.p.)	15	15
D2-BIO (Middle Dose)	4.5 x 1010 v.p./kg (i.c./i.p.)	15	15
D2-BIO SC (Middle Dose)	4.5 x 1010 v.p./kg (s.c.)	5	5
C-TOX (Control)	0 (i.c./i.p.)	25	25
D1-TOX (Low Dose)	4.5 x 109 v.p./kg (i.c./i.p.)	20	20
D2-TOX (Middle Dose)	4.5 x 1010 v.p./kg (i.c./i.p.)	20	20
D2-TOX CP (Middle Dose)	4.5 x 1010 v.p./kg (i.c./i.p.); 20mg/kg (i.p.)	20	20
D2-TOX SC (Middle Dose)	4.5 x 1010 v.p./kg (s.c.)	5	5
D3-TOX (High Dose)	4.5 x 1011 v.p./kg (i.c./i.p.)	25	25

BIO–bio-distribution groups, TOX–toxicity groups

ONCOS-102—Test item, Cyclophosphamide/CP–additive item

v.p./kg—virus particles per kg

(i.c./i.p.)–intracardial/intraperitoneal administration, (s.c./SC)–subcutaneous administration