Figure 1.

Improvement in BPI-SF average pain scores as a function of depressive episode (first [A] vs at least second [B]) for duloxetine- and SSRI-treated patients.

Notes: *Statistically significant difference favoring duloxetine, P<0.05. Number of patients at baseline – (A) first depressive episode: duloxetine n=139; SSRIs n=136; (B) ≥2 depressive episodes: duloxetine n=79; SSRIs n=76.

Abbreviations: BPI-SF, Brief Pain Inventory-Short Form; LS, least squares; n, number of affected patients at post-baseline week 12; SE, standard error; SSRIs, selective serotonin reuptake inhibitors.