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. 2017 Aug 4;11:2301–2324. doi: 10.2147/DDDT.S133944

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© 2017 Ahmed et al. This work is published and licensed by Dove Medical Press Limited

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This figure depicts the role and conformational changes necessary for K1419 to allow sodium permeation. Figure (A) and (B) give a top and side view for K1419 in a representative “off-state” where K1419 is coordinated to E898 and S1710 blocking the ion permeation pathway. Figure (C) and (D) depicts K1419 in an “on-state” allowing sodium permeation through the pore. (D) SOD1 and SOD2 seems to facilitate the permeation of SOD3 which reaches the central cavity afterwards giving raise to SOD3`` (violet). Upon the release of SOD3 to the central cavity, K1419 readopts an “off-state”, blocking the permeation of more sodium ions and preventing SOD3 from traveling in the reverse direction.