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The hydration of sodium ion at the outer SF (A) and the central cavity (B). As we can see in (A), water molecules allow sodium to slide through the filter by satisfying the H-bods of the negatively charged SF residues, which are E375, E901, D1423, and D1714. In (B), inner and outer SF residues shown as green and violet batches, respectively, over the cartoon representation of the hNav1.5 protein.
Abbreviation: SF, selectivity filter.
