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. Author manuscript; available in PMC: 2018 Jul 10.
Published in final edited form as: Cancer Cell. 2017 Jul 10;32(1):115–128.e7. doi: 10.1016/j.ccell.2017.06.001

Figure 7. Pharmacological inhibition of CAMKIIγ destabilizes the c-Myc protein and effectively reduces tumor burden.

Figure 7

(A) Thymuses obtained from mice suffering MNU-induced lymphoma treated as indicated (n = 4).

(B) Paraffin sections of thymuses in (A) analyzed by H&E staining.

(C) Kaplan-Meier survival curves of mice suffering MNU-induced lymphoma treated as indicated (n = 8 mice per group).

(D) Indicated proteins in tissue lysates from thymuses in (A) were detected using the Western blot analysis. Tissue lysates from wild-type thymuses with or without MNU injection only were shown as expression controls.

(E) Tumor volume comparison between indicated treatment groups at indicated time points after cell inoculation (n = 6 mice per group).

(F) Indicated proteins in xenografted tumor lysates from indicated treatment groups were detected using the Western blot analysis.

Data represent the mean ± s.d. *p < 0.05, **p < 0.01. See also Figures S7 and S8.