Fig. 3.

Study 1 - reported maximum local pain following each IM injection.

^aPain score 0 = No pain; Pain score 1 = Pain is present, but does not interfere with activity; Pain score 2 = Pain interferes with activity; Pain score 3 = Pain prevents daily activity.

Dots represent maximum individual pain reported after each vaccination at different doses. The blue line represents the average pain score as a function of dose. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)