Fig. 6.

Study 1 and Study 2 - individual antibody responses of subjects receiving vaccines by IM route.

Only subjects with antibody levels available on each analysis time point are included. Panel A: Subjects with no detectable antibody at baseline. Subjects with zero detectable antibody were assigned a value of 2 ELISA units (half the detectable limit) to enable plotting. Panel B: subjects with detectable antibody at baseline. Subjects were vaccinated on day 1, 29 and 57 with 0.059/1 μg (blue), 0.29/5 μg (green), 1.5/25 μg (light orange), 2.9/50 μg (dark orange), or 5.9/100 μg (red). Solid line: subjects in Study 1. Dashed green line: subjects in Study 2. Broad pink line: median antibody in the high dose group (subjects receiving ≥ 1.5/25 μg). Broad pale blue line: median antibody in the low dose group (0.059/1 μg and 0.29/5 μg). Dotted line: median antibody (121 ELISA units) measured in convalescent sera. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)