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. 2017 Aug 10;12(8):e0181685. doi: 10.1371/journal.pone.0181685

Fig 2. IL-1β concentrations in the supernatant of cultured peripheral leukocytes.

Fig 2

* P<0.05. (A) There were no differences in IL-1β concentrations between the gout and hyperuricemia groups following MSU stimulation alone, but IL-1β concentrations increased significantly in gout patients following MSU + ATP stimulation. (B) MSU + ATP stimulation significantly elevated IL-1β in patients with rs1653624 who carried the gout susceptibility genotype AA or AT; there was no difference IL-1β concentrations after MSU stimulation alone. (C) There were no significant differences between patients who carried the gout susceptibility genotype of rs7958316 or rs17525809 after MSU + ATP stimulation. (D) IL-1β concentrations in patients who carried the rs7958316 susceptibility genotype (TT) increased significantly after MSU + ATP stimulation compared to patients who carried the rs17525809 susceptibility genotype (AA or AG), but there were no differences in patients who carried the rs17525809-non-susceptible genotypes (GG).