Fig 2. Circulating levels of angiogenic T cells (Tang) correlate with severity of peripheral vascular damage in systemic sclerosis (SSc) patients.

(A) Representative CD31 versus CXCR4 dot plots of a SSc patient without digital ulcers (DU) and a SSc patient with DU. (B) Percentages of circulating CD3⁺CD31⁺CXCR4⁺ Tang cells in total CD3⁺ T cells from HC (n = 18), SSc patients without DU (n = 21) and SSc patients with DU (n = 18). (C) Percentages of circulating CD3⁺CD31⁺CXCR4⁺ Tang cells in total CD3⁺ T cells from HC (n = 18), SSc patients with early/active nailfold videocapillaroscopy (NVC) patterns (n = 20) and SSc patients with late NVC pattern (n = 19). Each box represents the 25th to 75th percentiles. Lines inside the boxes represent the median. Lines outside the boxes represent the 10th and the 90th percentiles. Circles indicate outliers. Differences were evaluated by Mann–Whitney U test.