Table 2. Changes in pre- and post-chemotherapy diameters of the target lesion on CT and volumes of the phantoms on 3D US, and corresponding response evaluation according to the unidimensional (1D) RECIST criteria and three-dimensional (3D) volumetric criteria.
| No. | Unidimensional RECIST Criteria* | Volumetric Criteria** | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CT volume | 3D US volumetric US (R1) | 3D US volumetric US (R2) | ||||||||||||||
| Baseline (cm) |
Post-Tx. (cm) |
Size Change | Criteria | Baseline (mL) |
Post-Tx. (mL) |
Volume Change | Criteria | Baseline (mL) |
Post-Tx. (mL) |
Volume Change | Criteria | Baseline (mL) |
Post-Tx. (mL) |
Volume Change | Criteria | |
| 1 | 1.8 | 1 | 44.5% D | PR | 5.15 | 1.06 | 79.4% D | PR | 4.63 | 0.8 | 82.7% D | PR | 4.38 | 1.27 | 71.0% D | PR |
| 2 | 3.3 | 1.8 | 45.5% D | PR | 15.65 | 3.12 | 80.1% D | PR | 14.94 | 3.1 | 79.3% D | PR | 18.57 | 3.1 | 83.3% D | PR |
| 3 | 2.2 | 1.5 | 31.8% D | PR | 6.46 | 2.86 | 55.8% D | SD | 5.13 | 4.63 | 9.7% D | SD | 8.32 | 5.72 | 31.3% D | SD |
| 4 | 4 | 1.5 | 62.5% D | PR | 20.5 | 2.0 | 90.2% D | PR | 21.33 | 2.32 | 89.1% D | PR | 24.14 | 1.88 | 22.1% D | PR |
| 5 | 3.3 | 2 | 39.4% D | PR | 18.27 | 4.24 | 76.8% D | PR | 13.7 | 4.45 | 67.5% D | PR | 20.25 | 4.62 | 77.2% D | PR |
| 6 | 3.4 | 2.3 | 32.4% D | PR | 18.4 | 5.92 | 67.8% D | PR | 14.89 | 7.42 | 50.2% D | SD | 15.16 | 5.97 | 60.6% D | SD |
| 7 | 2.4 | 1.4 | 41.7% D | PR | 5.41 | 1.31 | 75.7% D | PR | 3.91 | 1.3 | 66.8% D | PR | 4.83 | 1.51 | 68.7% D | PR |
| 8 | 2.7 | 1.4 | 48.1% D | PR | 6.04 | 1.61 | 73.4% D | PR | 6.22 | 0.98 | 84.2% D | PR | 5.12 | 1.43 | 72.1% D | PR |
| 9 | 3 | 2.1 | 30% D | PR | 8.74 | 4.79 | 45.2% D | SD | 8.12 | 2.98 | 63.3% D | SD | 7.62 | 4.65 | 39.0% D | SD |
| 10 | 3.9 | 1.6 | 59.0% D | PR | 10.14 | 3.06 | 69.8% D | PR | 13.07 | 3.78 | 71.1% D | PR | 13.12 | 3.73 | 71.6% D | PR |
| 11 | 2.9 | 2.4 | 17.2% D | SD | 10.02 | 5.04 | 49.7% D | SD | 7.12 | 4.41 | 38.1% D | SD | 9.72 | 5.13 | 47.2% D | SD |
| 12 | 2.8 | 3.3 | 17.9% I | SD | 11.74 | 14.75 | 25.7% I | SD | 11.25 | 12.98 | 15.4% I | SD | 13.33 | 15.84 | 18.8% I | SD |
| 13 | 3.3 | 2.8 | 15.2% D | SD | 15.66 | 21.16 | 35.1% I | SD | 13.81 | 23.1 | 67.3% I | SD | 14.86 | 24.93 | 67.8% I | SD |
| 14 | 1.2 | 1.8 | 50% I | PD | 1.09 | 2.06 | 89.7% I | PD | 0.91 | 2.82 | 209.9% I | PD | 1.02 | 2.43 | 138.2% I | PD |
| 15 | 2.8 | 2.0 | 28.6% D | SD | 9.53 | 3.57 | 62.6% D | SD | 8.82 | 4.19 | 52.5% D | SD | 8.82 | 5.24 | 40.6% D | SD |
| 16 | 2.4 | 2.4 | 0% | SD | 5.69 | 5.39 | 5.2% D | SD | 8.14 | 7.34 | 9.8% D | SD | 8.07 | 7.18 | 11.0% D | SD |
| 17 | 1.6 | 1.8 | 12.5% I | SD | 6.09 | 5.87 | 3.6% D | SD | 9.79 | 6.83 | 30.2% D | SD | 9.5 | 8.1 | 14.7% D | SD |
| 18 | 1.1 | 1.2 | 9.1% I | SD | 0.72 | 1.09 | 50.1% D | SD | 1 | 1.16 | 16% I | SD | 1.54 | 2.1 | 36.4% I | SD |
| 19 | 1.6 | 2.7 | 68.8% I | PD | 3.5 | 8.85 | 153.2% I | PD | 3.38 | 5.4 | 59.8% I | SD | 5.69 | 8.7 | 52.9% I | SD |
| 20 | 2.6 | 2.8 | 7.7% I | SD | 6.94 | 13.24 | 90.8% I | PD | 6.45 | 10.7 | 65.9% I | SD | 7.77 | 16.96 | 118.3% I | PD |
*1D RECIST criteria: PR- at least 30% decrease; PD- at least 20% increase; SD- between 30% decrease and 20% increase in diameter
**3D criteria: PR- at least 65% decrease; PD- at least 73% increase; SD- between 65% decrease and 73% increase in volume
D: decrease, I: increase