Table 2. Contribution of the major differentially expressed immune parameters discriminating Mtb-specific immune signatures of TB patients from TZ and SA identified by principal component analysis.
| Axes | Variance (%) | Immune parameters | Correlation | P value |
|---|---|---|---|---|
| Dim1 | 36.6% | T-bethigh | 0.827 | 3.4E-19 |
| Dim1 | 36.6% | IFN-β | 0.767 | 3.9E-15 |
| Dim1 | 36.6% | IFN-γ | 0.635 | 2.1E-09 |
| Dim1 | 36.6% | IFN-γ/TNF-α | 0.277 | 0.018 |
| Dim1 | 36.6% | IL-5 | -0.284 | 0.018 |
| Dim1 | 36.6% | IFN-γ/TNF-α/IL2 | -0.303 | 0.010 |
| Dim1 | 36.6% | Gata-3 | -0.800 | 3.5E-17 |
| Dim2 | 18% | IFN-γ/TNF-α | 0.835 | 7.5E-20 |
| Dim2 | 18% | IFN-γ/TNF-α/IL2 | 0.670 | 1.2E-10 |
| Dim2 | 18% | IL-5 | -0.302 | 0.010 |
| Dim3 | 15% | IL-5 | 0.838 | 4.2E-20 |
| Dim3 | 15% | IFN-γ/TNF-α/IL2 | 0.483 | 1.7E-05 |
| Dim3 | 15% | Gata-3 | -0.288 | 0.014 |
Abbreviations: T-bethigh, percentage of memory CD4 T cells expressing high level of T-bet; IFN-β, serum level of IFN-β; IFN-γ, proportion of single IFN-γ producing Mtb-specific CD4 T cells; IFN-γ/TNF-α, proportion of dual IFN-γ/TNF-α producing Mtb-specific CD4 T cells; IL-5, level of IL-5 detected in supernatants of Mtb-stimulated cell cultures; IFN-γ/TNF-α/IL-2, proportion of polyfunctional IFN-γ/TNF-α/IL-2 producing Mtb-specific CD4 T cells; Gata-3, percentage of memory CD4 T cells expressing Gata-3.