Table 3. Dogs less than 12 weeks of age.
| RABIES ANTIBODY TITER VALUES** | |||||||
|---|---|---|---|---|---|---|---|
| LOW RESPONDERS | MODERATE RESPONDERS | HIGH RESPONDERS | CMH± p-value | Geometric Mean Titer | P-Value* | ||
| Age at Vaccination: Under 12 Weeks | Sex | ||||||
| Male | 24 (15.9%) | 63 (41.7%) | 64 (42.4%) | 0.51 | 1.15 (0.14–1.63) | referent | |
| Female | 24 (17.9%) | 55 (41.0%) | 55 (41.0%) | 1.26 (0.91–1.75) | 0.80 | ||
| Unspecified | 0 | 2 (40.0%) | 3 (60.0%) | 3.1 (0.98–9.58) | 0.02 | ||
| Time from Vaccine Administration to Titer Check | |||||||
| ≤ 3 days | 0 | 0 | 0 | <0.01 | - | - | |
| 4 to ≤ 7 days | 1 (25%) | 1 (25%) | 2 (50%) | 1.42 (0.27–7.39) | 0.54 | ||
| 8 to ≤ 14 days | 0 | 0 | 2 (100%) | 4.14 (2.89–5.93) | 0.43 | ||
| 15 to ≤ 30 days | 3 (5.9%) | 16 (31.4%) | 32 (62.8%) | 2.51 (1.99–3.16) | referent | ||
| 31 to ≤ 90 days | 22 (18.3%) | 50 (41.7%) | 48 (40.0%) | 1.21 (0.87–1.68) | <0.01 | ||
| 91 to ≤ 180 days | 19 (26.4%) | 31 (43.1%) | 22 (30.6%) | 0.55 (0.28–1.12) | <0.01 | ||
| 180 to ≤ 270 days | 2 (5.9%) | 19 (55.9%) | 13 (38.2%) | 2.05 (1.58–2.66) | 0.12 | ||
| ≥ 270 days | 1 (14.3%) | 3 (42.9) | 3 (42.9%) | 1.46 (0.67–3.19) | 0.14 | ||
| Type of Dog | |||||||
| Mixed Breed | 16 (20.3%) | 23 (29.1%) | 40 (50.6%) | 0.03 | 1.15 (0.71–1.85) | 0.66 | |
| Pure Breed | 32 (15.2%) | 97 (46.0%) | 82 (38.9%) | 1.25 (0.96–1.64) | referent | ||
| Dog Size | |||||||
| Toy | 3 (6.5%) | 21 (45.7%) | 22 (47.8%) | 0.46 | 1.99 (1.53–2.58) | 0.42 | |
| Small | 9 (16.1%0 | 25 (44.6%) | 22 (39.3%) | 1.47 (0.97–2.25) | referent | ||
| Medium | 7 (18.9%) | 18 (48.7%) | 12 (32.4%) | 0.95 (0.55–1.75) | 0.50 | ||
| Large | 11 (17.7%) | 28 (45.2%) | 23 (37.1%) | 0.98 (0.55–1.75) | 0.44 | ||
| Giant | 1 (14.3%) | 3 (42.9%) | 3 (42.9%) | 0.60 (0.03–10.70) | 0.80 | ||
| Unspecified | 17 (20.7%) | 25 (30.5%) | 40 (48.8%) | 1.15 (0.72–1.82) | 0.14 | ||
| TOTAL | 48 (16.6%) | 120 (41.4%) | 122 (42.1%) | 1.22 (1.11–1.33) | |||
* P-value obtained from multivariable linear regression model of all variables represented in table 3, for the prediction of the geometric mean titer (GMT):
GMT = 3.19 + female * (0.05) + sex unspecified * (1.91) + mixed breed * (0.44) + toy * (0.28) + medium * (-0.25) + large * (-0.24) + giant * (0.17) + draw delay 7 days * (-0.55) + draw delay 14 days * (0.98) + draw delay 90 days * (-0.96) + draw delay 180 days * (-1.32) + draw delay 270 days * (-0.59) + draw delay 360 days * (-1.02)
** low responders are dogs with a titer < 0.5 IU/ml, high responders are dogs with a titer >1.5 IU/ml
±Cochran-Mantel-Haenszel