Table 4. Dogs 12–16 weeks of age.
| RABIES ANTIBODY TITER VALUES** | |||||||
|---|---|---|---|---|---|---|---|
| LOW RESPONDERS | MODERATE RESPONDERS | HIGH RESPONDERS | CMH± p-value | Geometric Mean Titer | P-value* | ||
| Age at Vaccination: 12–16 Weeks | Sex | ||||||
| Male | 185 (16.8%) | 472 (42.8%) | 445 (40.4%) | 0.28 | 1.17 (1.04–1.32) | referent | |
| Female | 159 (14.2%) | 480 (42.7%) | 485 (43.2%) | 1.27 (1.13–1.42) | 0.15 | ||
| Unspecified | 2 (16.7%) | 7 (58.3%) | 3 (25.0%) | 0.53 (0.10–2.62) | 0.14 | ||
| Time from Vaccine Administration to Titer Check | |||||||
| ≤ 3 days | 7 (100.0%) | 0 (0.0%) | 0 (0.0%) | <0.01 | 0.01 (0.00–0.15) | <0.01 | |
| 4 to ≤ 7 days | 1 (25.0%) | 2 (50.0%) | 1 (25.0%) | 0.23 (0.00–35.52) | 0.43 | ||
| 8 to ≤ 14 days | 4 (9.1%) | 17 (38.6%) | 23 (52.3%) | 1.68 (1.00–2.81) | 0.72 | ||
| 15 to ≤ 30 days | 28 (5.4%) | 212 (40.6%) | 282 (54.0%) | 2.13 (1.92–2.37) | referent | ||
| 31 to ≤ 90 days | 97 (10.9%) | 384 (43.1%) | 411 (46.1%) | 1.56 (1.40–1.73) | <0.01 | ||
| 91 to ≤ 180 days | 131 (25.1%) | 237 (45.2%) | 155 (29.6%) | 0.74 (0.60–0.90) | <0.01 | ||
| 180 to ≤ 270 days | 75 (31.3%) | 104 (43.3%) | 61 (25.4%) | 0.51 (0.36–0.73) | <0.01 | ||
| ≥ 270 days | 3 (60.0%) | 2 (40.0%) | 0 (0.0%) | 0.03 (0.00–2.44) | <0.01 | ||
| Type of Dog | |||||||
| Mixed Breed | 55 (12.5%) | 204 (46.5%) | 180 (41.0%) | 0.09 | 1.44 (1.25–1.65) | 0.07 referent | |
| Pure Breed | 291 (16.2%) | 755 (42.0%) | 753 (41.9%) | 1.17 (1.06–1.28) | |||
| Dog Size | |||||||
| Toy | 51 (12.2%) | 160 (38.2%) | 208 (49.6%) | <0.01 | 1.51 (1.27–1.79) | 0.09 | |
| Small | 74 (14.8%) | 221 (44.3%) | 204 (40.9%) | 1.36 (1.16–1.59) | referent | ||
| Medium | 43 (16.9%) | 97 (38.0%) | 115 (45.1%) | 0.99 (0.73–1.34) | 0.76 | ||
| Large | 108 (20.6%) | 229 (43.7%) | 187 (35.7%) | 0.91 (0.74–1.11) | <0.01 | ||
| Giant | 10 (11.1%) | 45 (50.0%) | 35 (38.9%) | 1.43 (1.01–2.04) | 0.39 | ||
| Unspecified | 60 (13.3%) | 207 (45.9%) | 184 (40.8%) | 1.34 (1.15–1.56) | 0.05 | ||
| TOTAL | 346 (15.5%) | 959 (42.9%) | 933 (41.7%) | 1.21 (1.12–1.32) | |||
* P-value obtained from multivariable linear regression model of all variables represented in table 4, for the prediction of the geometric mean titer (GMT):
GMT = 2.87 + female * (0.10) + sex unspecified * (-0.68) + mixed breed * (0.84) + toy * (0.18) + medium * (-0.04) + large * (-0.29) + giant * (-0.15) + draw delay 3 days * (-2.74) + draw delay 7 days * (-0.63) + draw delay 14 days * (-0.09) + draw delay 90 days * (-0.38) + draw delay 180 days * (-1.04) + draw delay 270 days * (-1.21) + draw delay 360 days * (-1.94)
** low responders are dogs with a titer < 0.5 IU/ml, high responders are dogs with a titer >1.5 IU/ml
±Cochran-Mantel-Haenszel