Table 5. Dogs greater than 16 weeks of age.
| RABIES ANTIBODY TITER VALUES** | |||||||
|---|---|---|---|---|---|---|---|
| LOW RESPONDERS | MODERATE RESPONDERS | HIGH RESPONDERS | CMH± p-value | Geometric Mean Titer | ANOVA* p-value | ||
| Age at Vaccination: Over 16 Weeks | Sex | ||||||
| Male | 279 (10.0%) | 1,002 (35.9%) | 1,509 (54.1%) | 0.12 | 1.69 (1.59–1.80) | referent | |
| Female | 286 (10.8%) | 935 (35.4%) | 1,418 (53.7%) | 1.60 (1.49–1.72) | 0.67 | ||
| Unspecified | 5 (9.3%) | 28 (51.9%) | 21 (38.9%) | 1.44 (0.93–2.22) | 0.16 | ||
| Time from Vaccine Administration to Titer Check | |||||||
| ≤ 3 days | 41 (83.7%) | 4 (8.2%) | 4 (8.2%) | <0.01 | 0.02 (0.01–0.06) | <0.01 | |
| 4 to ≤ 7 days | 7 (8.4%) | 27 (32.5%) | 49 (59.0%) | 1.65 (1.01–2.69) | 0.09 | ||
| 8 to ≤ 14 days | 13 (4.4%) | 58 (19.7%) | 224 (75.9%) | 2.66 (2.31–3.06) | 0.16 | ||
| 15 to ≤ 30 days | 46 (3.1%) | 379 (25.3%) | 1,072 (71.6%) | 2.70 (2.57–2.85) | referent | ||
| 31 to ≤ 90 days | 160 (7.4%) | 821 (37.9%) | 1,188 (54.8%) | 1.86 (1.75–1.99) | <0.01 | ||
| 91 to ≤ 180 days | 231 (21.4%) | 523 (48.4%) | 327 (30.3%) | 0.86 (0.75–0.98) | <0.01 | ||
| 180 to ≤ 270 days | 72 (23.3%) | 153 (49.5%) | 84 (27.2%) | 0.75 (0.59–0.97) | <0.01 | ||
| ≥ 270 days | 0 | 0 | 0 | - | - | ||
| Type of Dog | |||||||
| Mixed Breed | 94 (8.3%) | 414 (36.4%) | 628 (55.3%) | 0.03 | 1.80 (1.64–1.99) | 0.59 | |
| Pure Breed | 476 (11.0%) | 1,551 (35.7%) | 2,320 (53.4%) | 1.61 (1.52–1.69) | referent | ||
| Dog Size | |||||||
| Toy | 121 (9.2%) | 452 (34.4%) | 740 (56.4%) | <0.01 | 1.74 (1.58–1.92) | <0.01 | |
| Small | 137 (10.7%) | 452 (35.4%) | 687 (53.8%) | 1.68 (1.53–1.83) | referent | ||
| Medium | 55 (10.2%) | 196 (36.5%) | 286 (53.3%) | 1.71 (1.48–1.96) | 0.98 | ||
| Large | 132 (12.8%) | 383 (37.2%) | 514 (50.0%) | 1.40 (1.24–1.57) | 0.04 | ||
| Giant | 29 (16.8%) | 61 (35.3%) | 83 (48.0%) | 1.20 (0.87–1.66) | 0.32 | ||
| Unspecified | 96 (8.3%) | 421 (36.5%) | 638 (55.2%) | 1.80 (1.64–1.98) | 0.81 | ||
| TOTAL | 570 (10.4%) | 1,965 (35.8%) | 2,948 (53.8%) | 1.64 (1.57–1.72) | |||
* P-value obtained from multivariable linear regression model of all variables represented in table 5, for the prediction of the geometric mean titer (GMT):
GMT = 3.27 + female * (0.02) + sex unspecified * (-0.30) + mixed breed * (0.19) + toy * (0.18) + medium * (-0.002) + large * (-0.14) + giant * (-0.13) + draw delay 3 days * (-2.68) + draw delay 7 days * (-0.30) + draw delay 14 days * (0.14) + draw delay 90 days * (-0.55) + draw delay 180 days * (-1.42) + draw delay 270 days * (-1.54)
** low responders are dogs with a titer < 0.5 IU/ml, high responders are dogs with a titer >1.5 IU/ml
±Cochran-Mantel-Haenszel