Table 4. Spearman correlation (ρ) between CSF-lactate and EDSS at the lumbar puncture (EDSSLP) and the yearly progression rate in the entire cohort, treatment-naïve PPMS patients (PPMSTN) and at the LP at the year of diagnosis (LPD).

	Entire cohort	PPMSTN	LPD
Correlation between CSF-lactate in (mmol/L) and EDSSLP	ρ = 0.2 (p = 0.07) (n = 80)	ρ = 0.2 (p = 0.3) (n = 33)	ρ = 0.3 (p = 0.03) (n = 66)
Correlation between CSF-lactate in (mmol/L) and yearly progression rate	ρ = 0.3 (p = 0.02) (n = 76)	ρ = 0.5 (p = 0.006) (n = 32)	ρ = 0.3 (p = 0.01) (n = 62)