Table 1. The minimum inhibitory concentration (MIC in μg/mL) and the minimum bactericidal concentration (MBC in μg/mL) of diphenylurea compounds 1 and 2 and a control antibiotic (vancomycin) screened against S. aureus and S. epidermidis isolates.
| 1 | 2 | Vancomycin | ||||
|---|---|---|---|---|---|---|
| S. aureus strain | MIC | MBC | MIC | MBC | MIC | MBC |
| S. aureus NRS107 | 4 | 4 | 8 | 8 | 1 | 2 |
| S. aureus ATCC 6538a | 4 | NDc | 8 | ND | 0.5 | ND |
| MRSA NRS123 (USA400) | 4 | 4 | 8 | 8 | 1 | 1 |
| MRSA NRS384 (USA300) | 4 | 4 | 8 | 16 | 0.5 | 0.5 |
| MRSA NRS387 (USA800) | 4 | 4 | 8 | 16 | 0.5 | 1 |
| MRSA NRS483 (USA1000) | 4 | 4 | 16 | 16 | 1 | 1 |
| MRSA NRS484 (USA1100) | 8 | 8 | 16 | 16 | 1 | 2 |
| VRS4b | 8 | 8 | 16 | 16 | 64 | >64 |
| VRS7b | 8 | 8 | 16 | 16 | 64 | >64 |
| VRS10b | 4 | 4 | 4 | 8 | >64 | >64 |
| VRS11ab | 4 | 4 | 8 | 8 | >64 | >64 |
| S. epidermidis NRS101a | 2 | ND | 4 | ND | 1 | ND |
aBiofilm-forming strain
bVancomycin-resistant S. aureus
cND = not determined