Table 2. The minimum inhibitory concentration (MIC in μg/mL) of vancomycin in the absence and presence of a subinhibitory concentration (½ × MIC) of diphenylurea compounds 1 or 2 against vancomycin-resistant S. aureus (VRSA) isolates.
VRSA strain | MIC of vancomycin | MIC of vancomycin + 1 | Fold re-sensitization of VRSA to vancomycin | MIC of vancomycin + 2 | Fold re-sensitization of VRSA to vancomycin |
---|---|---|---|---|---|
VRS4 | 512 | 4 | 127-fold | 64 | 7-fold |
VRS10 | 512 | 128 | 3-fold | 8 | 63-fold |