FIG. 10.

The free energy difference of the polyelectrolyte translocation from a vesicle for the strength of the potential, B = 400. $\mathrm{\Delta }F$ is the total free energy difference, while $\mathrm{\Delta }{F}_u$ and $\mathrm{\Delta }{F}_s$ are the energy and entropic parts for $c_s=2\mathrm{\text{mM}},\sigma =0.2∕{\mathrm{\text{nm}}}^2$, and q = 1/nm. (a) Vesicle radius is held constant. (b) The initial vesicle radius is the optimum radius, $R^{*}=12.9\mathrm{\text{nm}}$, and the final vesicle radius can be different from $R^{*}$.