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. Author manuscript; available in PMC: 2017 Oct 3.
Published in final edited form as: Oncogene. 2017 Apr 3;36(32):4562–4572. doi: 10.1038/onc.2017.67

Figure 5. PIKE-A and CDK4 complex additively promotes GBM tumorigenesis.

Figure 5

A, Additive effect of PIKE-A and CDK4 on cell proliferation in glioblastoma cells. PIKE-A, CDK4, and PIKE-A/CDK4 stably transfected human glioblastoma LN229 (A), U87MG (B), LN-Z308 (C), and C8-S astrocyte (D) cells were seeded in 96-well plates and cell proliferation were examined every day for total 4 days using MTT assay. B & C, Additive effect of PIKE-A and CDK4 on cell migration and invasion in glioblastoma cells. PIKE-A, CDK4, and PIKE-A/CDK4 stably transfected human glioblastoma LN229, U87MG, LN-Z308, and C8-S astrocyte cells were examined by cell migration and invasion and colony formation assays.