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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Retina. 2018 Jan;38(1):29–38. doi: 10.1097/IAE.0000000000001504

Figure 3.

Figure 3

Visualizing subretinal drusenoid deposits (SDD) progression by spectral domain optical coherence tomography (SD-OCT) is dependent on plane of section. A & B. Adaptive optics scanning laser ophthalmoscopy (AOSLO) images of the same retinal area taken at baseline and 14 months later. A stage 1 lesion (yellow arrowheads) at baseline progressed to stage 2, and a stage 2 lesion (red arrowheads) at baseline progressed to stage 3. Simultaneously, a stage 3 SDD (green arrowheads) imaged at baseline remained at the same stage and enlarged. A SDD in transition from stage 2 to stage 3 at baseline (magenta arrowheads) has fully developed to stage 3, and clearly grown above the ellipsoid zone (EZ) band. C-D (baseline), E & F (follow-up). The corresponding SD-OCT B-scans indicated by green arrow lines in (A) and (B), reveal stage-specific changes that are best appreciated in multiple scans (e.g., magenta disappears at levels C,E and grows in levels D,F). The subject (AMD-041) is a 73-year-old (at baseline) man (white non-Hispanic) with non-neovascular age-related macular degeneration (Age-Related Eye Disease Study grade 6, best-corrected visual acuity 20/25). An alternate labelling scheme not using color is available as Supplemental Digital Content 4. ELM: external limiting membrane. RPE-BrM: retinal pigment epithelium-Bruch’s membrane.