Figure 5.
Quantifying the burden of subretinal drusenoid deposits (SDD) using adaptive optics scanning laser ophthalmoscopy (AOSLO) at baseline and 14-month follow-up. A & B. Individual SDD affected areas in regions of interest (ROI) delineated in the AOSLO, indicated by green boxes in (C) and (D). C & D. The entire area containing SDD in the central 30° imaged by infrared scanning laser ophthalmoscopy at baseline and 14-month follow-up. E. The percentage of SDD affected area in the ROI assessed by AOSLO. F. The burden of SDD over the area containing SDD in the central 30°, which is a product of the percentage of ROI affected by SDD and the area containing SDD in the central 30°. The eye shown in the left column (Study Eye 1) is an 84-year-old (at baseline) woman (white non-Hispanic, AMD-022) with non-neovascular age-related macular degeneration (Age-Related Eye Disease Study grade 7, best-corrected visual acuity 20/20).