Table 3. Results of 10 SNPs Associations with IA.
| Gene Chr. |
SNP | Position | Function | M/m* | 80 patients with IA and 80 controls | 41 IA rupture and 39 non-rupture in 80 patients | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Class | Effect | MAF† | HWE p‡ | OR§ | p value§ | MAF† | OR§ | p value§ | ||||
|
LOX 5q23.2 |
rs10040971 | 122063842 | Intron | None | T/C | 0.04/0.03 | 1.00 | 1.42 | 0.770 | 0.06/0.03 | 2.47 | 0.444 |
| rs17148773 | 122067364 | Intron | None | C/T | 0.00/0.03 | 1.00 | 0.00 | 0.061 | 0.00/0.00 | NA | 1.000 | |
| rs3792801 | 122067715 | Intron | None | C/T | 0.04/0.10 | 1.00 | 0.41 | 0.081 | 0.06/0.03 | 2.47 | 0.444 | |
| rs2303656 | 122070281 | Intron | None | C/A | 0.00/0.07 | 1.00 | 0.00 | 8.2×10−4 | 0.00/0.00 | NA | 1.000 | |
| rs10519694 | 122071524 | Intron | None | C/T | 0.06/0.03 | 1.00 | 2.60 | 0.170 | 0.05/0.08 | 0.62 | 0.527 | |
| rs2956540 | 122073485 | Intron | None | C/G | 0.24/0.19 | 0.73 | 1.40 | 0.277 | 0.24/0.24 | 1.00 | 1.000 | |
| rs1800449 | 122077513 | R158Q | Benign | G/A | 0.15/0.18 | 1.00 | 0.83 | 0.650 | 0.16/0.14 | 1.15 | 0.827 | |
| rs3853401 | 122081992 | 5−4 kb | None | C/T | 0.06/0.07 | 1.00 | 0.81 | 0.818 | 0.04/0.08 | 0.46 | 0.320 | |
| rs3900446 | 122090980 | 5−13 kb | None | T/C | 0.11/0.01 | 1.00 | 20.15 | 4.8×10−5 | 0.07/0.15 | 0.43 | 0.135 | |
| rs763497 | 122091535 | 5−13 kb | None | A/G | 0.24/0.13 | 1.00 | 2.26 | 0.009 | 0.22/0.27 | 0.76 | 0.581 | |
Chr., chromosome; IA, intracranial aneurysm; NA, not available; OR, odds ratio; MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium; SNPs, single nucleotide polymorphisms.
*Major/minor allele type, †MAF in case (left) and control (right) groups, ‡HWE p-value for control group, §OR and p value were estimated from allelic association analysis using Fisher's exact test.