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. 2017 Aug 9;7:360. doi: 10.3389/fcimb.2017.00360

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Copyright © 2017 Contreras, Alberdi, Fernández De Mera, Krull, Nijhof, Villar and De La Fuente.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of A. phagocytophilum infection on I. scapularis highly differentially regulated genes and represented proteins. (A) Number of tick highly differentially regulated genes and differentially represented proteins that were up-regulated (Up), down-regulated (Down), over-represented (Over) and under-represented (Under) in response to pathogen infection. (B) Number of tick highly differentially regulated genes and differentially represented proteins that were up-regulated (Up), down-regulated (Down), over-represented (Over) and under-represented (Under) in response to pathogen infection, and identified at both mRNA and protein levels. (C) Venn diagram with highly differentially regulated genes that were identified in tick nymphs, midguts and salivary glands. (D) Venn diagram with highly differentially represented proteins that were identified in tick nymphs, midguts and salivary glands. The highly differentially regulated genes were selected as those with more than 50-fold (log2 normalized fold change > 5.64) difference between infected and uninfected tick samples (P < 0.00003). The highly differentially represented proteins were selected as those with more than 15-fold (log2 normalized fold change > 3.90) change between infected and uninfected tick samples (P < 0.00003). The quantitative transcriptomics and proteomics data for uninfected and A. phagocytophilum-infected I. scapularis nymphs, adult female midguts and salivary glands were obtained from previously published results (Ayllón et al., 2015).