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. 2017 Aug 10;7:7837. doi: 10.1038/s41598-017-08319-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic TonEBP, HMGB1, IL-6, and TNF-α expression in HFD/STZ-treated TonEBP^+/− mice. (a) Representative micrographs of TonEBP-immunostained liver sections; scale bar = 50 μm. Western blots and protein quantification of hepatic TonEBP (b), HMGB1 (c), IL-6 (d), and TNF-α (e). The mean values were obtained from at least three independent experiment (n = 6 mice per group). Cropped blots are displayed here and full-length blots are included in the Supplementary Information. Data are presented as the mean ± SEM. *P < 0.05 vs. control (CTL) normal diet-fed mice; ^† P < 0.05 vs. DM WT mice.