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. 2017 Aug 10;7:7725. doi: 10.1038/s41598-017-08134-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electropherograms obtained with the Bioanalyzer 2100 in miRNA-Ref and plasma samples. Examples of the profiles obtained from a miRNA-Ref sample at 10 ng/μL (a, Bio-PicoChip; (b), Bio-SmallChip), a miRNA-Ref sample at 1 ng/μL (c, Bio-PicoChip; (d), Bio-SmallChip), and a plasma sample (e, Bio-PicoChip; (f), Bio-SmallChip). The 10 ng/µL miRNA-Ref sample (a) was diluted to fit the detection range of the Bio-PicoChip (0.05–5 ng/µL) and the final concentration was calculated by applying the dilution factor to the value obtained by the Bioanalyzer. In the miRNA-Ref samples (a–d), the overall profile is consistent with the presence of ribosomic RNA enriched with small RNAs, whereas in plasma samples (e,f) only small RNAs, but no long RNAs, are present. All electropherograms include the corresponding quantification (in bold) and the RNA integrity number (RIN) number (in italics) obtained with the Bio-PicoChip (a,c,e) or just the quantification (in bold) with the Bio-SmallChip (b,d,f).