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. 2017 Aug 10;7:7817. doi: 10.1038/s41598-017-07532-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network analysis of the gene pathways* catalogued in the Panther database, which - directly or indirectly - are connected with AD upon activation with Hp(2-20). Protein interactions were analyzed with the STITCH (A) and STRING (B) tools. The former catalogues known or predicted interactions between chemicals and proteins; the latter known or predicted protein-protein interactions. *List of the pathways included in the figure: Alzheimer disease-amyloid secretase pathway, Alzheimer disease-presenilin pathway, Angiogenesis, VEG-F signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.